Ipamorelin vs Sermorelin

The discussion of growth hormone peptides often includes use of..

Ipamorelin vs Sermorelin

The discussion of growth hormone peptides often includes use of both Sermorelin and Ipamorelin. If you’re curious what the advantages and disadvantages of both these products, you’ve come to the right place. We’ll discuss both.

What is a growth hormone?

Both Ipamorelin and Sermorelin are growth hormones but what exactly does that mean? A growth hormone in nature is a hormone that stimulates growth, by definition. These are naturally occurring in both plants and animals. The most common way people view growth hormone is in how it relates to muscle building. Synthetically made growth hormones (or GHRPs – growth hormone releasing peptides) are manufactured specifically to achieve this goal. They are made to increase cellular growth, regeneration, repair injuries and cellular damage, regulate metabolism (this, aiding weight loss) and maintaining sugar levels. There are a wide range of products and supplements available on the market, each with specific uses and side effects. Many studies are tested on animals so, if that is important to you ethically, make sure you research each company and their animal testing procedures and policies.


First and foremost, Ipamorelin is a secretagogue. This means it is able to bind cellular receptors and cause some sort of response. The main change that is being sought is the stimulation of the pituitary gland, located in the hypothalamus section of the brain. Ipamorelin stimulates that gland to start secreting and inhibit the secretion of another chemical called somatostatin. One of those secretions boosts an insulin growth factor. This type of growth hormone has been shown to have a slower, more steady release than other types of GHRPs (again, short for growth hormone releasing peptides). According to recent animal based studies, Ipamorelin has proven to strengthen joints and connective tissue, increase their metabolism and also strengthen bones. It also does not impede the production of natural growth hormone. Some side effects in studies have been mild, such as headache, lightheadedness, retaining of water, tiredness and, occasionally, carpal tunnel syndrome. Monitor and report to your doctor.


Similar to Ipamorelin, Sermorelin is also a secretogogue which triggers the release of growth hormone from the brain’s pituitary gland. Animal studies have shown an increase of lean muscle and the growth of new muscle cells. It also works to boost the production of the body’s own natural growth hormones. There has also been a slight increase in immune system function found. Sermorelin has also been found to help with sleep and studies have shown that an increase in deep sleep is also very beneficial to the development of growth hormone and cell growth. A few side effects noted have included dizziness, headache, fatigue, itching and flushing. Monitor for more severe side effects like vomiting, hives and changes in your perception of taste. Call your doctor if any of these symptoms, including trouble swallowing, appear. It could be the sign of an allergic reaction and needs to be taken seriously.

Both Ipamorelin and Sermorelin have significant benefits in generating and boosting growth hormone. Speak with your doctor to decide which is right for you.

Related articles