The peptide ipamorelin is a growth hormone secretagouge and ghrelin mimetic developed by Novo Nordisk. It is very popular because it is relatively safe and does not cause the side effect of elevated hunger like other GHRPs. Peptides may seem confusing and intricate at first glance but the mechanism of action of ipamorelin will soon make perfect sense once you review its individual components as follows:
How Growth Hormone Grows Muscle
Ipamorelin is a growth hormone secretagogue variety. People who wish to improve their aesthetics usually seek to utilise this secretagouge. It isn’t exactly the growth hormone that leads to the development of lean muscle tissue. The muscular anabolism is simply one of the “side effects” of its release. The growth hormone triggers the release of a hormone called “IGF-1” (Insulin like Growth Factor 1) from the liver when it enters the bloodstream. This growth hormone derivative subsequently splits itself into two after muscular breakdown and instigates the anabolic process of repairing and evolving muscle cells.
How Ipamorelin Stimulates The Pituitary Gland
The stimulation of the pituitary gland lead to the elevation of growth hormone levels within the body. There are actually two growth hormones within the body. These hormones are IGF-1 and Growth Hormone Releasing Hormone (GHRH). The GHRH is used purely as a trigger for the release of the main growth hormone from the somatotrophic cells. When we take ipamorelin, it enters the bloodstream and makes its way to the hypothalamus in the brain. The hypothalamus then sends a signal to the pituitary gland to release GHRH which then processes into the somatotrophic cells where it activates them, leading to the subsequent release of human growth hormone.
How The GH Pulse Works
The growth hormone pulse whether naturally occurring or exogenously initiated relies entirely on the “hunger hormone” ghrelin. The brain has to believe that ghrelin is present. Ghrelin is released as a means of telling us to eat or specifically to ingest nutrients.
The necessary capitalization on nutrient intake ultimately kick starts the anabolic process which leads to muscle growth from the release of ghrelin and growth hormone.
How Ipamorelin Releases Ghrelin & Increases Gastric
Ipamorelin elevates the presence of ghrelin in the system following implementation as a natural result of the neurological excitement it incites. When implementing any peptide variety, you are placing your body in a scenario that is comparable to having a rapid and sustained elevation of ghrelin. This will bring about:
- Increased energy.
- Improved sleep and mood.
- Increased lean muscle mass.
- Decreased body fat.
- Increased healing ability.
- Increased collagen production.
The primary reasons why growth hormone peptides (including ipamorelin) trigger such a positive growth hormone response within the body is because they suppress somatostatin which is part of the body’s recall process. If somatostatin were able to operate at its normal capacity when we used ipamorelin, it would inevitably diminish its effects.
Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Ipamorelin only selectively releases GH at any dose. A mega-dose of ipamorelin results in a concurrent mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.